<h3>Objective:</h3> To describe the development of an electronic health records (EHR)-based registry that captures demographics and outcomes for a diverse population at a safety net hospital. <h3>Background:</h3> Disparities in Parkinson’s disease (PD) care are well documented. Evaluating practice disparities is important at Boston Medical Center (BMC) where 57% of patients are medically underserved. We sought to use EHR tools to examine barriers to standard PD care. <h3>Design/Methods:</h3> An EHR-based (EPIC, Epic Systems, Verona, WI) report was created using EPIC registry tools that leverage existing data in our EHR and organizes it for reporting and monitoring. The registry is composed of an inclusion rule, which defines criteria required for inclusion in the registry, and metrics that determine the information collected about each record. A workbench report was generated consisting of: patients with PD as diagnosis or problem, demographics, physical therapy (PT) details, and social determinants of health (SDOH). <h3>Results:</h3> 899 patients were included in report for analysis. 44% were female. Common languages spoken included English (79%), Spanish (8%), Haitian Creole (4%), Vietnamese (2%). Hispanic ethnicity was identified by 11%. Racial demographics included 57% White, 14% African-American/Black, 7% Hispanic, 4% Asian, and 16% declined/unknown. Referrals to PT were documented in 50% of patients (54% of these White, 19% African-American/Black, 8% Hispanic, 4% Asian and 13% declined//unknown). 9% had a BMC PT visit (39% of these African-American, 26% White, 15% Hispanic, 2% Asian and 14% declined/unknown). Top SDOH recorded were food insecurity, transportation need, and utility difficulties. <h3>Conclusions:</h3> We demonstrate the feasibility of creating an EHR-based registry to identify current practice patterns and SDOH. The data from the registry will allow for further exploration of barriers to standard PD care and innovative strategies to close gaps. Registry development may be feasible for PD clinics looking to capture baseline demographics, assess SDOH, and evaluate clinical outcomes. <b>Disclosure:</b> The institution of Dr. Bissonnette has received research support from Michael J Fox Foundation. The institution of Dr. Bissonnette has received research support from Cogan Family Foundation. Ms. Owen has nothing to disclose. Ms. Martin has received personal compensation for serving as an employee of Boston Medical Center. Ms. Martin has received personal compensation for serving as an employee of LCMC Health. Dr. Bird has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lundbeck. Mr. Stevenson has nothing to disclose. Mr. James has nothing to disclose. Ms. Lee has nothing to disclose. Abigail Desrosier has nothing to disclose. Prof. Ellis has received personal compensation in the range of $0-$499 for serving as a Consultant for MJFF. Prof. Ellis has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Neurologic Physical Therapy Professional Education onsortium. Prof. Ellis has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JNPT. The institution of Prof. Ellis has received research support from NIH. The institution of Prof. Ellis has received research support from MedRhyms Inc. Mr. Wendel has nothing to disclose. Dr. Bresler has nothing to disclose. Dr. Lee has nothing to disclose. Ms. Thomas has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avion. Dr. Saint-Hilaire has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acorda. Dr. Saint-Hilaire has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Altec. Dr. Saint-Hilaire has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Watermark. Dr. Saint-Hilaire has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Parkinson study group. Dr. Shih has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Encora Therapeutics. Dr. Shih has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine. Dr. Shih has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Praxis Precision Medicines. Dr. Shih has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Supernus. Dr. Shih has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for WCG Medavante. Dr. Shih has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medtronic. Dr. Shih has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley . The institution of Dr. Shih has received research support from Abbott. The institution of Dr. Shih has received research support from Praxis Precision Medicines. Dr. Shih has received personal compensation in the range of $500-$4,999 for serving as a Consultant with German Accelerator.